The presentation by Precision's Marlon Graf of a study with Jim Baumgardner, Iris Brewer, Jacquelyn Chou and Oliver Diaz and their colleagues was named an ISPOR 2023 Research Presentation Award Finalist. The Generalized Risk-Adjusted Cost-Effectiveness framework is a generalization of conventional cost-effectiveness analysis (CEA) and incorporates the effects of diminishing returns to health improvements as severity of illness increases. In the study presented by Marlon, the GRACE framework was applied to assess the comprehensive value of direct-acting antivirals (DAAs) for the treatment of hepatitis C (HCV) compared to peginterferon alfa and ribavirin (PEG/riba), accounting for differential valuations of life years versus quality of life, disease severity, insurance value, and other novel value elements. Please reach out to Marlon to learn more about the GRACE framework.

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The presentation by Precision's Dylan Maciel of a study with Shannon Cope, Kevin Towle and Jeroen Jansen and their colleagues was named an ISPOR 2023 Research Presentation Award Finalist. Multi-level network meta-regression (ML-NMR) is a new method to perform network meta-analysis where for a subset of the studies we have individual participant data and for the remaining studies only aggregate level data from publications. In the study presented by Dylan, the feasibility of implementing ML-NMR for survival outcomes was evaluated. We learned a lot from this study that has direct benefit to future PRECISIONheor studies. Please contact Shannon Cope to learn more about ML-NMR (which is a method that is generalization of early work published by our Chief Scientist, Jeroen Jansen, in 2012).

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The presentation by Precision's Laura Panattoni of a study with Tom Flottemesch, Natalie Land and Patrick Sullivan and their colleagues at ISPOR 2023 was named the Best General Podium Research Presentation. With this study, Laura and her colleagues aimed to quantify preferences for first line treatment attributes and treatment profiles among physicians who treat patients with aUC in 5 European countries (France, Germany, Italy, Spain, and the UK) with a DCE. Overall survival was the dominant attribute driving physicians’ choice of first line therapy, indicating that future therapies for aUC will need to provide substantial survival benefit to influence prescribing preferences. Reach out to Laura to learn more about this study.

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